How p53 wields the scales of fate
نویسندگان
چکیده
Understanding how the tumor suppressor p53 induces cell cycle arrest or apoptosis is critical for developing chemotherapeutic strategies. We have generated targeted transgenic reporter mice with which we can study p53 activity at specific promoters, and propose a model in which p53 protein conformation is key to target gene selection.
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2012